PGT-M is a laboratory test that is used to help detect single gene conditions prior to pregnancy to greatly reduce the risk of having an affected child.
Some patients may choose to include preimplantation genetic testing for aneuploidy (PGT-A) in addition to PGT-M to reduce the risk of chromosome abnormalities as well as the familial genetic condition.
A PGT-M test is designed for every family’s unique mutation, using a technique called linkage analysis, which creates DNA markers around the gene that carries the mutation. This technology allows for PGT-M tests to be designed within 6 weeks.
Following test design, IVF would then take place. A sample is taken from the embryo on day 5 or day 6 of development. The embryo is then frozen while the sample is sent to the laboratory for testing.
Yes, scientific studies have shown that embryo biopsies do not add risk factors to the health of babies born after IVF.
No test can guarantee that a baby will not have any medical issues. PGT-M does not test for all genetic and non-genetic problems that may be present in a baby. Genetic counselling before and after testing is recommended.
The whole process can take up to 4-5 months to complete.
The initial genetic counselling, testing of family members, and test preparation can take approximately 6-8 weeks.
Once the test is prepared, IVF treatment can commence. The embryos will have to be biopsied, and the sample cells sent to the PGT-M lab for testing. This can take up to another 6 weeks.
It recommended that you do not start any IVF treatment (controlled ovarian hyperstimulation) before the test design process is complete. During this time, you will have a genetic counselling session to understand the process and the different possible outcomes to ensure that you do wish to proceed with PGT-M before undertaking any IVF treatment.
No, unfortunately medical aids do not currently cover PGT-M.