PharmaGene Icon What is the PharmaGene Test?

PharmaGene is a pharmacogenomic test in South Africa that analyses how your genes influence your response to medication.

This medication genetic testing helps guide safer and more effective prescribing.

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What is the PharmaGene Test?

What is Pharmacogenomics?

Pharmacogenomics studies how genetic variations affect:

Drug metabolism

Drug metabolism

Medication effectiveness

Medication effectiveness

Risk of side effects

Risk of side effects

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How Genetics Affect Medication Response

Metabolise drugs too slowly

Metabolise drugs too slowly

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Increased side effects

Increased side effects

Metabolise drugs too quickly

Metabolise drugs too quickly

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Reduced effectiveness

Reduced effectiveness

PharmaGene identifies these patterns to support personalised medication decisions.

Who Can Benefit from Pharmacogenomic Testing?

  • Individuals on multiple medications
  • Patients experiencing side effects
  • Those with poor treatment response
  • Anyone planning future medication use

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Clinical Decision Support

Healthcare providers can:

  • Review medication compatibility
  • Adjust dosages
  • Reduce risk of adverse reactions
  • Optimise treatment outcomes

How the Test Works

Complete test requisition form

Complete test requisition form

Collect saliva sample

Collect Saliva sample

Results in 3 to 4 weeks

Results in 3 to 4 weeks

Reviewed with healthcare provider

Reviewed with healthcare provider

PharmaGene Sample Report Patient Test Requisition Form

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Frequently Asked Questions

Find answers to common questions about Pharmacogenomic Testing:

Pharmacogenomic testing looks at specific genes that influence how your body absorbs, metabolises, and responds to medications. This helps identify whether a standard dose or drug is likely to work well for you, work poorly, or cause side effects, based on your unique genetic makeup. The goal is to support safer, more effective medication decisions.

PharmaGene can identify genetic factors that increase your risk of certain adverse drug reactions or reduced drug effectiveness, giving your doctor valuable insight before prescribing. However, medication response is also influenced by other factors like age, lifestyle, and overall health, so it cannot predict every possible outcome with certainty.

No, you do not need to be currently taking medication to benefit from PharmaGene testing. Because your genetic profile does not change, results can be kept on file and referred to whenever a new medication is prescribed, now or years into the future.

People taking multiple medications, those who have experienced unexpected side effects or poor results from a drug, and patients starting treatment for chronic conditions often benefit most. It is also valuable for anyone wanting a proactive, one-time test that can inform medication choices throughout their life.

No, PharmaGene does not diagnose any medical condition. It is specifically focused on how your body is likely to respond to medications, giving your doctor extra information to guide prescribing decisions alongside your diagnosis and treatment plan.

By revealing how your body processes specific drugs, PharmaGene allows your doctor to choose medications and dosages more precisely suited to your genetics, rather than relying on a standard, population-average approach. This can help reduce trial-and-error prescribing, minimise side effects, and improve the chances of a medication working effectively the first time.

Results are typically available within 4 weeks of the lab receiving your sample, after which they can be shared with your prescribing doctor to inform current or future treatment decisions.

Yes, PharmaGene is available in South Africa through Next Biosciences, giving local patients and doctors access to genetic insights that support safer, more personalised medication decisions.

References

  • Jarvis, J et al. Real-World Impact of a Pharmacogenomics-Enriched Comprehensive Medication Management Program. J. Pers. Med. 2022, 12(3), 421