AmnioRederm

AmnioRederm is a placental membrane biological wound dressing designed to naturally stimulate the recovery of non-healing soft tissue wounds from as early as 1 month¹.

AmnioRederm as an Advanced Wound Therapy in non-healing or hard-to-heal wounds²:

As a specialised adjunctive therapy, AmnioRederm is designed to naturally stimulate the recovery of non-healing soft tissue wounds. It is made from human placental membrane, consisting of the amnion and chorion, which is a collagen rich structure. The placental membrane is mechanically separated from the placenta under aseptic conditions, before being enzymatically treated to remove epithelial cells from the membrane surface, therefore no living cells are exposed to the patient. Further to this, the structure of the placental membrane itself acts as a natural cellular scaffold, allowing for cellular adhesion and mobility.

Dehydrated placental membrane provides natural healing properties to wounds with minimal inflammation and scarring.

The benefits of AmnioRederm include:

Promotes epithelialisation³(Provides a structure for cellular migration and proliferation)
Reduces time to healing³
Helps in pain reduction at affected site³
Reduces overall treatment costs at the affected site⁴
Contains collagen types IV, V and VII which promote cellular differentiation and adhesion
Anti-inflammatory effect
Bacteriostatic effect
Anti-adhesive and supportive in preventing scarring
Assists with pain and discomfort at affected site
Known to be non-immunogenic and low in antigenicity

Indications	Contraindications
Diabetic ulcers Venous leg ulcers Pressure ulcers Partial thickness facial burns Scald, flame, and electrical burns	AmnioRederm should NOT be implanted onto: Areas with an active or latent infection On patients with a history of drug reactions to Ciprofloxacin or Amphotericin B
*This product is intended for single patient use.*

AmnioRederm is intended to be used as an adjunctive to the normal standard of care for small to medium wound healing applications.

It is specifically designed to enhance the recovery of soft tissue wounds, especially chronic non-healing wounds such as diabetic ulcers and lesions. AmnioRederm is a thin membrane applied directly to the wound.

Prior to using AmnioRederm, a thorough initial assessment of the wound is necessary, as is a medical history.

These are the same steps that you would follow prior to implementing any wound treatment and are not specific to amniotic membrane treatment:

Gather information on the history of the wound, including duration, what treatments have been tried and patient comorbidity.
Document wound appearance, size, depth, presence of necrotic tissue.
Note whether bone or other structures are visible.
Assess circulatory status, nutrition, and other barriers to healing. Prepare the wound bed by performing any necessary debridement.
The wound bed should be clear of any necrotic tissue and should not have any signs of infection.
Remove the membrane from the polyester net and place it on the wound. The membrane should cover the edges of the wound. If necessary, use two or three membranes to cover wound area to the edges.
Remove the membrane from the polyester net and place it on the wound. The membrane should cover the edges of the wound. If necessary, use two or three membranes to cover wound area to the edges.
Reassess after 7 days.

Collection

Placental donations are collected during the birthing process in accordance with the National Health Act of South Africa. All donors complete a health questionnaire and are screened for transmissible diseases. All AmnioRederm samples are tested during processing for bacterial and fungal contamination and to ensure sterility of the product.

Packaging

The amniotic membrane is spread on a polyester net with the epithelial side orientated onto the net. The membrane is dehydrated, cut to size and packaged aseptically in an inner polyethylene pouch and sealed with an outer peel pouch. Dehydrated denuded human amniotic membrane is terminally sterilised by gamma-irradiation.

Storage

AmnioRederm can be stored in a clean dry setting at room temperature for up to 4 years from date of manufacture. No special storage is needed for this product.

AmnioRederm is dispatched in an unopened, original packaging.
It should be stored at room temperature (10-28°C).
Use within 4 years from the day of production (expiry date will be printed on each AmnioRederm product label).

Available sizes:

DHAM2030 - 20x30mm

DHAM4060 - 40x60mm

Package Insert

Case Study - Chronic Device Pressure Injury

Case Study - Pressure Sore In Lower Limb

Order Form

Case Study - Chronic Venous Stasis Ulcer

GC Boersema, H Smart, M Giaquinto-Cilliers, M Mulder, GR Weir, FA Bruwer, PJ Idensohn, JE Sander, A Stavast, M Swart, S Thiart, Z Van Der Merwe. Management of non-healable and maintenance wounds: a systematic integrative review and referral pathway. Wound Healing Southern Africa: 2021 Volume 14, No 1 p8-16.
Data from AmnioRederm package insert
Zelen, C. M., Serena, T. E., Denoziere, G., & Fetterolf, D. E. (2013a). A prospective randomised comparative parallel study of amniotic membrane wound graft in the management of diabetic foot ulcers. International Wound Journal, 10(5), 502–507. https://doi.org/10.1111/iwj.12097.
Zelen, C. M., Serena, T. E., Gould, L., Le, L., Carter, M. J., Keller, J., & Li, W. W. (2015). Treatment of chronic diabetic lower extremity ulcers with advanced therapies: a prospective, randomised, controlled, multi-centre comparative study examining clinical efficacy and cost. International Wound Journal, 13(2), 272–282. https://doi.org/10.1111/iwj.12566

A collagen rich biological product designed to naturally stimulate the recovery of non-healing soft tissue wounds

AmnioRederm is a placental membrane biological wound dressing designed to naturally stimulate the recovery of non-healing soft tissue wounds from as early as 1 month1.

AmnioRederm as an Advanced Wound Therapy in non-healing or hard-to-heal wounds2: