Comprehensive list of diseases treated:
Standard therapies (cord blood) – these are diseases in which stem cell transplants are a standard treatment. In some cases they are the only therapy, and in others they are employed when first line treatments have failed, or if the disease is particularly aggressive.
Leukaemia
Diagnosis | Allogeneic | Autologous |
Acute Lymphoblastic Leukaemia (ALL) | X | |
Acute Myelogenous Leukaemia (AML) | X | |
Acute Biphenotypic Leukaemia | X | |
Acute Undifferentiated Leukaemia | X | |
Chronic Lymphocytic Leukaemia (CLL) | X | |
Chronic Myelogenous Leukaemia (CML) | X | |
Juvenile Chronic Myelogenous Leukaemia (JCML) | X | |
Juvenile Myelomonocytic Leukaemia (JMML) | X |
Myelodysplastic Syndromes
Diagnosis | Allogeneic | Autologous |
Refractory Anaemia | X | |
Sideroblastic anaemia | X | |
Refractory Anaemia with Excess Blasts | X | |
Refractory Anaemia with Excess Blasts in Transformation | X | |
Chronic Myelomonocytic Leukaemia (CMML) | X |
Lymphoma
Diagnosis | Allogeneic | Autologous |
Hodgkin’s Lymphoma | X | |
Non-Hodgkin’s Lymphoma | X |
Other Disorders of Blood Cell Proliferation
Diagnosis | Allogeneic | Autologous |
Anaemias | ||
Aplastic Anaemia | X | X |
Fanconi’s Anaemia | X | see gene therapy trials |
Congenital Dyserythropoietic Anaemia | X | |
Paroxysmal Nocturnal Haemoglobinuria (PNH) | X | |
Inherited Red Cell Abnormalities | ||
Sickle Cell Disease | X | |
Beta Thalassemia Major | X | |
Diamond-Blackfan Anaemia | X | |
Pure Red Cell Aplasia | X | |
Inherited Platelet Abnormalities | ||
Amegakaryocytosis / Congenital Thrombocytopenia | X | |
Glanzmann Thrombasthenia | X | |
Inherited Immune System Disorders: Severe Combined Immunodeficiency | ||
SCID with Adenosine Deaminase Deficiency (ADA-SCID) | X | |
SCID which is X-linked | X | |
SCID with absence of T & B Cells | X | |
SCID with absence of T Cells, Normal B Cells | X | |
Omenn Syndrome | X | |
Inherited Immune System Disorders: Neutropenias | ||
Infantile Genetic Agranulocytosis (Kostmann Syndrome) | X | |
Myelokathexis | X | |
Inherited Immune System Disorders: Other | ||
Ataxia-Telangiectasia | X | |
Bare Lymphocyte Syndrome | X | |
Common Variable Immunodeficiency | X | |
DiGeorge Syndrome | X | |
Haemophagocytic Lymphohistiocytosis | X | |
Leukocyte Adhesion Deficiency | X | |
Lymphoproliferative Disorders | X | |
Lymphoproliferative Disorder, X-linked (Susceptibility to Epstein-Barr virus) | X | |
Wiskott-Aldrich Syndrome | X | |
Myeloproliferative Disorders | ||
Acute Myelofibrosis | X | |
Agnogenic Myeloid Metaplasia (Myelofibrosis) | X | |
Polycythemia Vera | X | |
Essential Thrombocythaemia | X | |
Phagocyte Disorders | ||
Chediak-Higashi Syndrome | X | |
Chronic Granulomatous Disease | X | |
Neutrophil Actin Deficiency | X | |
Reticular Dysgenesis | X | |
Plasma cell disorders | ||
Multiple Myeloma | X | X |
Plasma Cell Leukaemia | X | X |
Waldenstrom’s Macroglobulinaemia | X | X |
Transplants for Inherited Disorders of the Immune System & Other Organs
Diagnosis | Allogeneic | Autologous |
Cartilage-Hair Hypoplasia | X | |
Erythropoietic Porphyria | X | |
Hermansky-Pudlak Syndrome | X | |
Pearson’s Syndrome | X | |
Shwachman-Diamond Syndrome | X | |
Systemic Mastocytosis | X |
Transplants for Inherited Metabolic Disorders
Diagnosis | Allogeneic | Autologous |
Mucopolysaccharidosis (MPS) Storage Diseases | ||
Hurler Syndrome (MPS-IH) | X | |
Scheie Syndrome (MPS-IS) | X | |
Hunter Syndrome (MPS-II) | X | |
Sanfilippo Syndrome (MPS-III) | X | |
Morquio Syndrome (MPS-IV) | X | |
Maroteaux-Lamy Syndrome (MPS-VI) | X | |
Sly Syndrome (MPS-VII) (beta-glucuronidase deficiency) | X | |
Mucolipidosis II (I-cell Disease) | X | |
Leukodystrophy Disorders | ||
Adrenoleukodystrophy (ALD) | X | |
Krabbe Disease(Globoid Cell Leukodystrophy) | X | |
Metachromatic Leukodystrophy | X | |
Pelizaeus-Merzbacher Disease | X | |
Lysosomal Storage Diseases | ||
Niemann-Pick Disease | X | |
Sandhoff Disease | X | |
Wolman Disease | X | |
Other Inherited Metabolic Disorders | ||
Lesch-Nyhan Syndrome | X | |
Osteopetrosis | X |
Solid tumors not originating in the blood or immune system
Diagnosis | Allogeneic | Autologous |
Neuroblastoma | X | |
Medulloblastoma | X | |
Retinoblastoma | X |
Copyright Frances Verter PhD, PGCB, 2014