Comprehensive list of diseases treated:
Standard therapies (cord blood) – these are diseases in which stem cell transplants are a standard treatment. In some cases they are the only therapy, and in others they are employed when first line treatments have failed, or if the disease is particularly aggressive.
Leukaemia
| Diagnosis | Allogeneic | Autologous |
| Acute Lymphoblastic Leukaemia (ALL) | X | |
| Acute Myelogenous Leukaemia (AML) | X | |
| Acute Biphenotypic Leukaemia | X | |
| Acute Undifferentiated Leukaemia | X | |
| Chronic Lymphocytic Leukaemia (CLL) | X | |
| Chronic Myelogenous Leukaemia (CML) | X | |
| Juvenile Chronic Myelogenous Leukaemia (JCML) | X | |
| Juvenile Myelomonocytic Leukaemia (JMML) | X |
Myelodysplastic Syndromes
| Diagnosis | Allogeneic | Autologous |
| Refractory Anaemia | X | |
| Sideroblastic anaemia | X | |
| Refractory Anaemia with Excess Blasts | X | |
| Refractory Anaemia with Excess Blasts in Transformation | X | |
| Chronic Myelomonocytic Leukaemia (CMML) | X |
Lymphoma
| Diagnosis | Allogeneic | Autologous |
| Hodgkin’s Lymphoma | X | |
| Non-Hodgkin’s Lymphoma | X |
Other Disorders of Blood Cell Proliferation
| Diagnosis | Allogeneic | Autologous |
| Anaemias | ||
| Aplastic Anaemia | X | X |
| Fanconi’s Anaemia | X | see gene therapy trials |
| Congenital Dyserythropoietic Anaemia | X | |
| Paroxysmal Nocturnal Haemoglobinuria (PNH) | X | |
| Inherited Red Cell Abnormalities | ||
| Sickle Cell Disease | X | |
| Beta Thalassemia Major | X | |
| Diamond-Blackfan Anaemia | X | |
| Pure Red Cell Aplasia | X | |
| Inherited Platelet Abnormalities | ||
| Amegakaryocytosis / Congenital Thrombocytopenia | X | |
| Glanzmann Thrombasthenia | X | |
| Inherited Immune System Disorders: Severe Combined Immunodeficiency | ||
| SCID with Adenosine Deaminase Deficiency (ADA-SCID) | X | |
| SCID which is X-linked | X | |
| SCID with absence of T & B Cells | X | |
| SCID with absence of T Cells, Normal B Cells | X | |
| Omenn Syndrome | X | |
| Inherited Immune System Disorders: Neutropenias | ||
| Infantile Genetic Agranulocytosis (Kostmann Syndrome) | X | |
| Myelokathexis | X | |
| Inherited Immune System Disorders: Other | ||
| Ataxia-Telangiectasia | X | |
| Bare Lymphocyte Syndrome | X | |
| Common Variable Immunodeficiency | X | |
| DiGeorge Syndrome | X | |
| Haemophagocytic Lymphohistiocytosis | X | |
| Leukocyte Adhesion Deficiency | X | |
| Lymphoproliferative Disorders | X | |
| Lymphoproliferative Disorder, X-linked (Susceptibility to Epstein-Barr virus) | X | |
| Wiskott-Aldrich Syndrome | X | |
| Myeloproliferative Disorders | ||
| Acute Myelofibrosis | X | |
| Agnogenic Myeloid Metaplasia (Myelofibrosis) | X | |
| Polycythemia Vera | X | |
| Essential Thrombocythaemia | X | |
| Phagocyte Disorders | ||
| Chediak-Higashi Syndrome | X | |
| Chronic Granulomatous Disease | X | |
| Neutrophil Actin Deficiency | X | |
| Reticular Dysgenesis | X | |
| Plasma cell disorders | ||
| Multiple Myeloma | X | X |
| Plasma Cell Leukaemia | X | X |
| Waldenstrom’s Macroglobulinaemia | X | X |
Transplants for Inherited Disorders of the Immune System & Other Organs
| Diagnosis | Allogeneic | Autologous |
| Cartilage-Hair Hypoplasia | X | |
| Erythropoietic Porphyria | X | |
| Hermansky-Pudlak Syndrome | X | |
| Pearson’s Syndrome | X | |
| Shwachman-Diamond Syndrome | X | |
| Systemic Mastocytosis | X |
Transplants for Inherited Metabolic Disorders
| Diagnosis | Allogeneic | Autologous |
| Mucopolysaccharidosis (MPS) Storage Diseases | ||
| Hurler Syndrome (MPS-IH) | X | |
| Scheie Syndrome (MPS-IS) | X | |
| Hunter Syndrome (MPS-II) | X | |
| Sanfilippo Syndrome (MPS-III) | X | |
| Morquio Syndrome (MPS-IV) | X | |
| Maroteaux-Lamy Syndrome (MPS-VI) | X | |
| Sly Syndrome (MPS-VII) (beta-glucuronidase deficiency) | X | |
| Mucolipidosis II (I-cell Disease) | X | |
| Leukodystrophy Disorders | ||
| Adrenoleukodystrophy (ALD) | X | |
| Krabbe Disease(Globoid Cell Leukodystrophy) | X | |
| Metachromatic Leukodystrophy | X | |
| Pelizaeus-Merzbacher Disease | X | |
| Lysosomal Storage Diseases | ||
| Niemann-Pick Disease | X | |
| Sandhoff Disease | X | |
| Wolman Disease | X | |
| Other Inherited Metabolic Disorders | ||
| Lesch-Nyhan Syndrome | X | |
| Osteopetrosis | X |
Solid tumors not originating in the blood or immune system
| Diagnosis | Allogeneic | Autologous |
| Neuroblastoma | X | |
| Medulloblastoma | X | |
| Retinoblastoma | X |
Copyright Frances Verter PhD, PGCB, 2014