Clinical Trials with Cord Blood Stem Cells
Table 1. Stem Cell Clinical Trials where children use their own (autologous) Cord Blood Stem Cells
Diagnosis | Occurrence in USA | Trial stage | Trial registry |
Acquired Hearing Loss | 12.5% ages 6-19 | phase 1 | NCT01343394 NCT02038972 |
Autism | 1.5% (1 in 68) children | phase 2 phase 1 |
NCT01638819 NCT02176317 India |
Cerebral Palsy | 0.2% full term births, 2.2% premature births, 1 in 300 kids ages 5-10 |
phase 2 | NCT01147653 NCT01072370 NCT01988584 Japan |
Cerebral Palsy | (see above) | phase 1 | Romania Slovakia Spain |
Hypoplastic Left Heart Syndrome | 0.2 per 1000 births | phase 1 | NCT01445041 NCT01856049 |
Neonatal Oxygen Deprivation | 0.2% full term births | phase 1 | NCT00593242 NCT01506258 NCT01649648 Japan |
Stroke (pre-/peri-natal) | 1 per 3500 births | phase 1 | NCT02460484 |
Traumatic Brain Injury | 435,000 per yr ages 0-14 #1 cause of death in kids |
phase 1 | NCT01251003 NCT01700166 |
Type 1 Diabetes | 1.7 per 1000 ages birth-19 | phase 1 & 2 | NCT00989547 NCT00873925 CoRD |
Table copyright Frances Verter, PhD 2014
Table 2. Stem Cell Clinical Trials using donor (allogeneic, includes siblings) Cord Blood Stem Cells
Diagnosis | Occurrence in USA | Trial stage | Trial registry |
Cartilage Repair | 10-25% adolescents have knee injuries |
Approved by Korean FDA (Cartistem) |
NCT01733186 |
Cerebral Palsy | 2 per 1000 full term births | phase 2 | NCT01193660 NCT01528436 NCT01639404 NCT01991145 NCT02025972 |
Critical Limb Ischemia | 2.5 per 1000 people, over 80% of them diabetics |
phase 1 | NCT01019681 |
Premature Lungs (BPD) | 25% births under 1500gm | phase 2 | NCT01897987 |
Type 1 Diabetes | 1.7 per 1000 ages birth-19 | phase 2 | NCT01350219 NCT01996228 |
Table copyright Frances Verter, PhD 2014